itraconazole (itr  (BASF)

Journal: Pharmaceutics

Article Title: Composition Dependency of the Flory–Huggins Interaction Parameter in Drug–Polymer Phase Behavior

doi: 10.3390/pharmaceutics15122650

Figure Lengend Snippet: Molecular structure of drugs: ( a ) acetaminophen, ( b ) itraconazole, ( c ) griseofulvine and polymers, ( d ) basic butylated methacrylate copolymer, ( e ) Soluplus ® , and ( f ) vinylpyrrolidone/vinyl acetate copolymer.

Article Snippet: The drugs acetaminophen (ACE) (Caelo, Caesar & Loretz GmbH, Hilden, Germany), itraconazole (ITR) (BASF SE, Ludwigshafen, Germany) and griseofulvin (GRI) (Hawkins, Roseville, MN, USA) cover a broad spectrum of molecular weight ( ).

Techniques:

Journal: Pharmaceutics

Article Title: Composition Dependency of the Flory–Huggins Interaction Parameter in Drug–Polymer Phase Behavior

doi: 10.3390/pharmaceutics15122650

Figure Lengend Snippet: Flory–Huggins interaction parameter depending on the drug volume fraction of solid dispersions containing the drugs acetaminophen ( top ), itraconazole ( middle ), griseofulvine ( bottom ), and the polymers basic butylated methacrylate copolymer ( left ), Soluplus ® ( middle ), and polyvinylpyrrolidone/vinyl acetate copolymer ( right ).

Article Snippet: The drugs acetaminophen (ACE) (Caelo, Caesar & Loretz GmbH, Hilden, Germany), itraconazole (ITR) (BASF SE, Ludwigshafen, Germany) and griseofulvin (GRI) (Hawkins, Roseville, MN, USA) cover a broad spectrum of molecular weight ( ).

Techniques:

Journal: Pharmaceutics

Article Title: Composition Dependency of the Flory–Huggins Interaction Parameter in Drug–Polymer Phase Behavior

doi: 10.3390/pharmaceutics15122650

Figure Lengend Snippet: Phase behavior of solid dispersions containing the drugs acetaminophen ( top ), itraconazole ( middle ), griseofulvine ( bottom ), and the polymers basic butylated methacrylate copolymer ( left ), Soluplus ® ( middle ), and vinylpyrrolidone/vinyl acetate copolymer ( right ). The literature data from Wolbert et al. are taken from their Supplementary Materials.

Article Snippet: The drugs acetaminophen (ACE) (Caelo, Caesar & Loretz GmbH, Hilden, Germany), itraconazole (ITR) (BASF SE, Ludwigshafen, Germany) and griseofulvin (GRI) (Hawkins, Roseville, MN, USA) cover a broad spectrum of molecular weight ( ).

Techniques:

Journal: Frontiers in Cellular and Infection Microbiology

Article Title: Synergistic effect of pyrvinium pamoate and posaconazole against Cryptococcus neoformans in vitro and in vivo

doi: 10.3389/fcimb.2022.1074903

Figure Lengend Snippet: Galleria mellonella survival curves following infection with Cryptococcus neoformans . Untreated group, uninfected larvae; Saline group, larvae injected with saline; yeast group, larvae infected with C. neoformans without any treatment; POS, C. neoformans -infected larvae treated with posaconazole (POS) alone; POS+PP, C. neoformans -infected larvae treated with POS combined with pyrvinium pamoate (PP); ITR, C. neoformans -infected larvae treated with itraconazole alone; ITR+PP, C. neoformans -infected larvae treated with ITR combined with PP; VOR, C. neoformans -infected larvae treated with voriconazole alone; VOR+PP, C. neoformans -infected larvae treated with VOR combined with PP; FLU, C. neoformans -infected larvae treated with fluconazole alone; FLU+PP, C. neoformans -infected larvae treated with FLU combined with PP; AmB, C. neoformans -infected larvae treated with amphotericin B alone; AmB+PP, C. neoformans -infected larvae treated with AmB combined with PP; PP, C. neoformans -infected larvae treated with PP alone (* p < 0.05. **** p < 0.0001).

Article Snippet: All drugs, including itraconazole (ITR) (Lot No. s2476), voriconazole (VOR) (Lot No. s1442), posaconazole (POS) (Lot No., s1257), FLU (Lot No. s1331), PP (lot No.5816), and AmB (lot No.1636) were both purchased as powders from Selleck.cn, were dissolved in dimethyl sulfoxide or water (FLU) to a concentration of 6400ug/ml and stored at – 20°C.

Techniques: Infection, Saline, Injection